ALFREDO CRAVADOR

Professor catedrático jubilado

  
Curriculum vitae
    

Nome: Alfredo Jaime Morais Cravador

    

Naturalidade: Santarém

    
 
Qualificações Académicas:

Agregação Ensino Superior - Universidade do Algarve - 1994

Doutoramento - Université Libre de Bruxelles (U.L.B.) - 1976

Licenciatura - Université Libre de Bruxelles (U.L.B.) - 1972
Actividades anteriores e situação actual em termos científicos e/ou profissionais:

Fevereiro de 1996 - presente: Professor catedrático da Universidade do Algarve.

Junho de 1992 - Fevereiro de 1996: Professor associado da Universidade do Algarve, Agregado desde 7/1994.

Outubro de 1989 - Agosto de 1992: Consultor da sociedade SmithKline Beecham (Segurança Biológica dos Processos Biotecnológicos e Impacte Ambiental).

Outubro de 1988 - Setembro de 1989: Director científico da Empresa de Investigação e Desenvolvimento em Biotecnologia BIOEID.

1981 - 1988: Investigador na Université Libre de Bruxelles (U.L.B.).

1984(2 meses) e 1986 (5 meses) - Consultor Científico Internacional no Centro de Recursos Genéticos (CENARGEN) da Sociedade de Estado Brasileira EMBRAPA, em Brasília.

1977 - 1981: Investigador assistente das Facultés Universitaires Notre-Dame de la Paix (Universidade de Namur).
Actuais interesses de investigação:

Domains and research programmes:

  • Study of the decline disease of Quercus suber and Quercus rotundifolia aiming at the management of the genetic/biological control of the disease. Studies on molecular interactions Phytophthora cinnamomi-Quercus suber in connection with the infectious process.

      •Identification and characterization of cork oak and holm oak trees tolerant to the decline disease associated with Phytophthora cinnamomi and evaluation of genetic and biological measures for its control.
      •The transcriptome analysis (ESTs) of Q. suber roots directed to genes related to biotic stress caused by Phytophthora cinnamomi infection.
      •Identification and production of active compounds against Phytophthora cinnamomi by Phlomis purpurea.
      •Metabolome and transcriptome analysis of Phlomis purpurea a plant resistant to Phytophthora cinnamomi.

  • Study of candidate genes as molecular markers in dairy indigenous species. Genetic and morphological characterization of indigenous bovine breeds.

 
  Línguas:
  • Português (materna)
  • Francês
  • Inglês
  • Castelhano
   
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Publicações:

  • Martins, Ivone M.; Meirinho, Sofia; Costa, Rodrigo; Cravador, Alfredo; Choupina, Altino. Cloning, characterization, in vitro and in planta expression of a necrosis‑inducing Phytophthora protein 1 gene npp1from Phytophthora cinnamomi. Molecular Biology Reports (2019). doi.org/10.1007/s11033-019-05091-0.

  • Jung, Thomas; Duran, Alvaro; Sanfuentes, Eugenio; Schena, Leonardo; Mosca, Saveria; Fajardo, Sebastian; González, Mariela; Navarro Ortega, Angella; Bakonyi, Jozsef; Seress, Diana; Tomšovský, Michal; Cravador, Alfredo; Maia, Cristiana; Horta Jung, Marília. Diversity of Phytophthora species in Valdivian rainforests and association with severe dieback symptoms. Forest Pathology (2018). DOI: 10.1111/efp.12443.

  • Baldé, A.; Neves, D.; García-Breijo, F.J; Pais, M.S.; Cravador, A. De novo assembly of Phlomis purpurea after challenging with Phytophthora cinnamomi. BMC Genomics, 18:700 (2017). DOI 10.1186/s12864-017-4042-6.

  • Thomas Jung, Marília Horta Jung, Santa Olga Cacciola, Thomas Cech, József Bakonyi, Diána Seress, Saveria Mosca, Leonardo Schena, Salvatore Seddaiu, Antonella Pane, Gaetano Magnano di San Lio, Cristiana Maia, Alfredo Cravador, Antonio Franceschini, and Bruno Scanu. Multiple new cryptic pathogenic Phytophthora species from Fagaceae forests in Austria, Italy and Portugal. IMA FUNGUS, 8(2): 219–244 (2017). doi:10.5598/imafungus.2017.08.02.02.

  • Jung, T., Scanu, B., Bakonyi, J., Seress, D., Kovács, G.M., Durán, A., Sanfuentes von Stowasser, E., Schena, L., Mosca, S., Thu, P.Q., Nguyen, C.M., Fajardo, S., González, M., Pérez–Sierra, A, Rees, H., Cravador, A., Maia, C., Horta Jung, M.. Nothophytophthora gen. nov., a new sister genus of Phytophthora from natural and semi–natural ecosystems in Europe, Chile and Vietnam. Persoonia – Molecular Phylogeny and Evolution of Fungi, 39 (2017). doi.org/10.3767/persoonia.

  • Mateus, M.C.; Neves, D.; Dacunha, B.; Laczko, E.; Maia, C.; Teixeira, R.; Cravador, A. Structure, anti-Phytophthora and anti-tumor activities of a nortriterpenoid from the rhizome of Phlomis purpurea (Lamiaceae), Phytochemistry, 131: 158-164 (2016). DOI information: 10.1016/j.phytochem.2016.09.004.

  • T. Jung, L. Orlikowski, B. Henricot, P. Abad-Campos, A. G. Aday, O. Agu_ın Casal, J. Bakonyi, S. O. Cacciola, T. Cech, D. Chavarriaga, T. Corcobado, A. Cravador et al., Widespread Phytophthora infestations in European nurseries put forest, semi-natural and horticultural ecosystems at high risk of Phytophthora diseases. Forest Pathology, 46: 134-163 (2016). DOI: 10.1111/efp.12239.

  • Ebadzad, G.; Medeira, C; Maia, I; Martins J. and Cravador A. Induction of defence responses by cinnamomins against Phytophthora cinnamomi in Quercus suber and Quercus ilex subs. rotundifolia. European Journal of Plant Pathology, 143 (4), 705-723 (2015). DOI: 10.1007/s10658-015-0721-9.

  • Pereira-Leal, J.B., Abreu, I.A., Alabaça, C.S.,  Almeida, M.H., Almeida, P., Almeida, T., Amorim, M.I., Susana, Azevedo, H., Badia, A., Batista, D.,  Bohn, A., Capote, T., Carrasquinho, I., Chaves, I., Coelho, A.C., Costa, M.M.R., Costa, R., Cravador, A., et al. A comprehensive assessment of the transcriptome of cork oak (Quercus suber) through EST sequencing. BMC Genomics, 15:371 (2014). DOI:10.1186/1471-2164-15-371.

  • Ebadzad, Ghazal; Cravador, Alfredo. Quantitative RT-PCR analysis of differentially expressed genes in Quercus suber in response to Phytophthora cinnamomi infection. SpringerPlus,  3:613 (2014). DOI:10.1186/2193-1801-3-613.

  • W. Oßwald, F. Fleischmann, D. Rigling, A.C. Coelho, A. Cravador, J. Diez, R.J.Dalio, M. Horta Jung, H. Pfanz, C. Robin, G. Sipos, A. Solla, T. Cech, A. Chambery, S. Diamandis, E. Hansen, T. Jung, L.B. Orlikowski, J. Parke, S. Prospero, S. Werres. Strategies of attack and defence in woody plant-Phytophthora interactions. Forest Pathology, 44 (3), 169–190 (2014). DOI: 10.1111/efp.12096.

  • Ivone M. Martins, Fátima Martins, Hélio Belo, Madalena Vaz, Marisa Carvalho, Alfredo Cravador and Altino Choupina. Cloning, characterization and in vitro and in planta expression of a glucanase inhibitor protein (GIP) of Phytophthora cinnamomi. Molecular Biology Reports, 41:2453–2462 (2014). DOI: 10.1007/s11033-014-3101-1.

  • Dina Neves, Paula Caetano, Joana Oliveira, Cristiana Maia, Marília Horta, Nelson Sousa, Marco Salgado, Lídia Dionísio, Naresh Magan and Alfredo Cravador. Anti-Phytophthora cinnamomi activity of Phlomis purpurea plant and root extracts, European Journal of Plant Pathology, 138:835-846 (2014). DOI: 10.1007/s10658-013-0357-6.

  • C. Medeira, V. Quartin, I. Maia, I. Diniz, M. C. Matos, J. Semedo1, P. Scotti-Campos1, J. Ramalho, I. Pais, P. Ramos, E. Melo, A. Leitão and A. Cravador. Cryptogein and capsicein promote defence responses in Quercus suber against Phytophthora cinnamomi infection European Journal of Plant Pathology, 134 (1), 145-159 (2012). DOI: 10.1007/s10658-012-9972-x.

  • H. R. Shahbazkia, M. Aminlari and A. Cravador. Association of polymorphism of the β(1, 4)-galactosyltransferase-I gene with milk production traits in Holsteins. Molecular Biology Reports, 39 (6), 6715-6721 (2012). DOI: 10.1007/s11033-012-1495-1.

  • Medeira, C; Maia, I; Ribeiro, C; Candeias, I; Melo E; Sousa, N; and Cravador, A. Alpha cinnamomin elicit a defence response against Phytophthora cinnamomi in Castanea sativa. Acta Hort. 940, ISHS, 315-320 (2012).

  • I. Maia, M. Horta, A. Cravador and C. Medeira. Loss of Aggressiveness of Phytophthora cinnamomi (Beta-Cinnamomin Silenced Strain) in the Infection of Castanea sativa. Microsc. Microanal. 18 (Suppl 5), (2012). DOI:10.1017/S1431927612012743.

  • Coelho, A.C., Ebadzad, G., Horta, M. & Cravador, A. Quercus suber – P. cinnamomi interaction: hypothetical molecular mechanism model. New Zealand Journal of Forestry Science, 41S: S143-S157 (2011). (ISSN 0048-0134 (print); ISSN 1179-5395 (on-line)).

    M. Horta, P. Caetano, C. Medeira, I. Maia and A. Cravador. Involvement of the b-cinnamomin elicitin in infection and colonisation of cork oak roots by Phytophthora cinnamomi. European Journal of Plant Pathology 127 (3) Page 427-436 (2010). DOI: 10.1007/s10658-010-9609-x.

  • C. Ginja, M. C. T. Penedo, M. F. Sobral, J. Matos, C. Borges, D. Neves, T. Rangel-Figueiredo and A. Cravador. Molecular genetic analysis of a cattle population for recovery of the extinct Algarvia breed. Genetics Selection Evolution 42:18 (2010). DOI: 10.1186/1297-9686-42-18.

  • H. R. Shahbazkia, M. Aminlari, A. Tavasoli, A. R. Mohamadnia and A. Cravador. Polymorphisms of the b-1,4 Galactosyltransferase-I Gene in Holsteins. Livestock Science 131 (2-3) Pages 297-30 (2010). DOI: 10.1016/j.livsci.2010.04.009.

  • H. R. Shahbazkia, M. Aminlari, A. Tavasoli, A. R. Mohamadnia and A. Cravador. Associations among Milk Production Traits and Glycosylated Haemoglobin in Dairy Cattle; Importance of Lactose Synthesis Potential. Veterinary Research Communications, 34, 1-9, 2010. DOI 10.1007/s11259-009-9324-2.

  • M. F. Sobral, C. Roberto, D. Navas, I. Palmilha, M. B. Lima and A. Cravador. Identification of descendants of an extinct bovine population from the Algarve region of Portugal using numerical taxonomy analysis of morphological traits. Journal of Animal Breeding and Genetics, 126(4), 319-326 (2009).

  • Maia, I., Medeira, C., Candeias, I.; Moreira, A., Melo, E. and Cravador, A. Exposition of cork oak roots to cryptogein reduced the Infection by Phytophtora cinnamomi. Microscopy and Microanalysis, 15 (supp 3), 27-28 (2009).

  • M. Horta; N. Sousa; A. C. Coelho; D. Neves and A. Cravador. In vitro and in vivo quantification of elicitin expression in Phytophthora cinnamomi, Physiological and Molecular Plant Pathology, 73, 48–57 (2008).

  • Maia, I.; Medeira, C.; Melo, E.; Cravador, A. Quercus suber infected by Phytophthora cinnamomi. Effects at cellular level of cinnamomin on roots, stem and leaves. Microscopy and Microanalysis, 14 (supp 3), 146-147 (2008).

  • Barracosa P., Lima M.B., Cravador A. Analysis of genetic diversity in Portuguese Ceratonia siliqua L. cultivars using RAPD and AFLP markers. Scientia Horticulturae, 118, 189–199 (2008).

  • P. Barracosa, J. Osório, A. Cravador. Evaluation of fruit and seed diversity and characterization of carob (Ceratonia siliqua L.) cultivars in Algarve region, Scientia Horticulturae, 114, 250-257 (2007).

  • Coelho, A. C., Horta, M., Neves, D.  and Cravador, A. Involvement of a cinnamyl alcohol dehydrogenase of Quercus suber in the defence response to infection by Phytophthora cinnamomi. Physiological and Molecular Plant Pathology, 69 62–72 (2006).

  • Estela Bastos, Sílvia Ávila, Alfredo Cravador, Robert Renaville, Henrique Guedes-Pinto, José Luis Castrillo. Identification and characterization of four splicing variants of ovine POU1F1 gene. Gene, 382, 12-19 (2006).

  • Coelho, A.C.; Lima, M.B.; Neves, D. and Cravador, A. Genetic diversity of two evergreen oaks (Quercus suber L. and Q (ilex) rotundifolia Lam.) in Portugal using AFLP markers. Silvae Genetica, 55(3), 105-118 (2006).

  • M. R. Marques, I. C. Santos, N. Carolino, C. C. Belo, R. Renaville and A. Cravador. Effects of genetic polymorphisms at the growth hormone gene on milk yield in “Serra da Estrela” sheep. Journal of Dairy Research, 73, 394-405 (2006).

  • Estela Bastos, Ingrid Santos, Isabelle Parmentier, José Luis Castrillo, Alfredo Cravador, Henrique Guedes-Pinto, Robert Renaville. Ovis aries POU1F1 gene: cloning, characterization and polymorphism analysis. Genetica, 12(3): 303-314 (2006).

  • Maria Luisa Rodrigues, Margarida Archer, Paulo Martel, Sandra Miranda, Mónica Thomaz, Francisco Javier Enguita, Ricardo P. Baptista, Eduardo Pinho e Melo, Nelson Sousa, Alfredo Cravador, Maria Arménia Carrondo. Crystal structures of the free and sterol-bound forms of b-cinnamomin. Biochimica et Biophysica Acta - Proteins and Proteomics, 1764, 110-121 (2006).

  • Renaville R., Parmentier I., Falahi M., Gengler N., Cravador A. et Portetelle D. Les marqueurs génétiques. In Théwis A., Bourbouse A., Compère R., Duplan J.-M., Hardouin J. (eds).  Manuel de Zootechnie comparée Nord-Sud. INRA editions, Paris, 353-367 (2005).

  • P. X. Marques, M. Pereira, M. R. Marques, I. C. Santos, C. Belo, R. Renaville and A. Cravador. Association of milk traits with SSCP polymorphisms at the growth hormone gene in the Serrana goat. Small Ruminant Research, Vol 50/1-2, 177-185 (2003).

  • Maria L. Rodrigues, Margarida Archer, Paulo Martel,, Alain Jacquet, Alfredo Cravador and Maria A. Carrondo. Crystal structure of b-cinnamomin, a toxic protein for some plant species. Acta Crystallographica, D58, 1314-1321 (2002).

  • C. Reis and A. Cravador. Pit-1 gene HinfI polymorphism detection in eight portuguese bovine breeds. Rev. Port. Zootecnia, ANO IX - 1, 21-28 (2002).

  • M. F. Sobral, A.Cravador, D.Navas, C.Roberto, C.Reis, M.B.Lima (2001). Classification and morphological characterization of native Portuguese cattle breeds using numerical taxonomy. Rev. Port. Zootecnia, ANO VIII - 2, 123-137 (2001).

  • E. Malveiro, M.Pereira, P.X: Marques, I.C. Santos, C. Belo, R. Renaville and A. Cravador. Polymorphisms at the five exons of gowth hormone gene in the Algarvia Goat. Possible association with milk traits. Small Ruminant Research 41(2), 163-170 (2001).

  • C. Reis, D. Navas, M. Pereira, A. Cravador. Growth hormone AluI polymorphism analysis in eight Portuguese bovine breeds. Archivos de Zootecnia 50 (189-190), 41-48 (2001).

  • E. Malveiro, P. X. Marques, I. C. Santos, C. Belo and A. Cravador. Association between SSCPs at Algarvia goat GH and milk traits. Archivos de Zootecnia 50 (189-190), 49-57 (2001).

  • C. Bonifácio, I. Santos, C. Belo and A. Cravador. Single-Strand Conformation Polymorphism (SSCP) analysis of alfa s1-casein, beta-casein and kapa-casein genes in Charnequeira Portuguese indigenous goat breed. Archivos de Zootecnia 50 (189-190), 105-112 (2001).

  • Estela Bastos, Alfredo Cravador, Jorge Azevedo, Henrique Guedes-Pinto. Single strand conformation polymorphism (SSCP) detection in six genes in the Portuguese indigenous sheep breed "Churra da Terra Quente". Biotecnol. Agron. Soc. Environ., 5 (1), 7-15 (2001).

  • M. Archer, M. L. Rodrigues, M. Aurélio, R. Biemans, A. Cravador, M. A. Carrondo Crystallisation and preliminary X-ray diffraction analysis of beta-cinnamomin, an elicitin secreted by the phytopathogenic fungus Phytophthora cinnamomi. Acta Cryst., D 56, 363-366 (2000).

  • J. Duclos, A. Fauconnier, A.C. Coelho, A. Bollen, A. Cravador and E. Godfroid. Identification of an elicitin gene cluster in Phytophthora cinnamomi; DNA Sequence 67, 231-237 (1998).

  • A. Cravador. Os DNA Sintéticos Anti-Sentido, Química Nova, 21 (4), 441 (1998).

  • A.C. Coelho, A. Cravador, A. Bollen, J.F.P. Ferraz, A.C. Moreira, A. Fauconnier and E.Godfroid. Highly specific and sensitive non-radioactive molecular identification of Phytophthora cinnamomi; Mycological Research, 101 (12): 1499-1507 (1997).

  • A. Cravador. Les oligonucléotides synthétiques “antisens” (1re partie); Chimie Nouvelle, 12(46), 1351 (1994).

  • A. Cravador. Les oligonucléotides synthétiques “antisens” (2e partie); Chimie Nouvelle, 12(47), 1377 (1994).

  • M.-J. De Vos, A. Cravador, J.-P. Lenders, S. Houard and A. Bollen. Solid Phase Non Isotopic Labelling of Oligodeoxynucleotides Using 5'-Protected Aminoalkyl Phosphoramidites: Application to the Specific Detection of Human Papilloma Virus DNA; Nucleosides & Nucleotides, 9(2), 259 (1990).

  • A. Cravador, A Herzog, S. Houard, P. d'Ippolito, R. Carrol and A. Bollen. Selective detection of Human Papilloma Virus DNAs by specific DNA probes; Molecular and Cellular Probes, 3, 143 (1989).

  • N. Moguilevsky, C. Roobol, R. Loriau. J.-P. Guillaume, P. Jacobs, A. Cravador, A. Herzog, L. Brouwers, A. Scarso, P. Gilles, L. Holmquist, L. A. Carlson and A. Bollen. Production of Human Recombinant Proapolipoprotein A-I in Escherichia coli: Purification and Biochemical Characterization; DNA, 8(6), 429 (1989).

  • Ciccarelli, E., Massaer, M., Guillaume, J.-P., Herzog, A., Loriau, R., Cravador, A., Jacobs, P., Bollen, A. Porcine D-amino acid oxidase: Production of the biologically active enzyme in Escherichia coli; Biochemical and Biophysical Research Communications, 161(2), 865-872 (1989).

  • M.Chaput, V.Claes, D.Portetelle, I.Cludts, A.Cravador, A.Burny, H.Gras, A.Tartar. The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase; Nature 332, 454 (1988).

  • H. Johansen, J. Sutiphong, G. Sathe, P. Jacobs, A. Cravador, A. Bollen, M. Rosenberg and A. Shatzman. High-level production of fully active human alpha1-antitrypsin in Escherichia coli, Mol. Biol. Med. 4, 291 (1987).

  • P. Jacobs, F. Brockly, M. Massaer, R. Loriau, J. P. Guillaume, E. Ciccarelli, M. Heinderyckx, A.Cravador, R. Biemans, A. Van Elsen, A. Herzog, A. Bollen. Porcine D-amino acid oxidase: determination of the mRNA nucleotide sequence by the characterization of genomic and cDNA clones; Gene, 59, 55 (1987).

  • L. Piérard, P. Jacobs, D. Gheysen, M. Hoylaerts, B. André, L. Topisirovic, A. Cravador, F. de Foresta, A. Herzog, D. Collen, M. De Wilde and A. Bollen.Mutant and chimaeric recombinant plasminogen activator: production in eukariot cells and preliminary characterization; J. Biol. Chem., 262(24), 11771-11778 (1987).

  • Pierard, L; Jacobs, P; Gheysen, D; Hoylaerts, M; Cravador, A; Herzog, A; Collen, D; Bollen, A. Mutant and chimeric recombinant plasminogen activators; Thrombosis and Haemostasis Vol. 58 (1), (1987). ISSN: 0340-6245.

  • M. Wathelet, S. Moutschen, A. Cravador, L. DeWit, P. Defilippi, G. Huez and J. Content. Full-length sequence and expression of the 42 kDa 2-5a synthetase induced by human interferon; FEBS Lett., 196, 113-120 (1986). DOI: 10.1016/0014-5793(86)80224-1.

  • Marc Wathelet, Sabine Moutschen, Paola Defilippi, Alfredo Cravador, Marc Collet, Georges Huez and Jean Content. Molecular cloning, full-length sequence and preliminary characterization of a 56 kDa protein induced by human interferon; Eur. J. Biochem., 155, 11-17 (1986). DOI: 10.1111/j.1432-1033.1986.tb09452.x.

  • Wathelet, M.; Moutschen, S.; Cravador, A.; Balzarini, J.; Content, J. and Huez, G. Complete sequence and possible role of the 56-kd protein-induced by human interferon. Archives Internationales de Physiologie de Biochimie et de Biophysique, Vol. 94 (1) (1986).

  • Wathelet, M.; Moutschen, S.; Cravador, A.; Huez, G. and Content, J. Full-length cDNA cloning and corresponding gene structure of the human 2'-5'a-synthetase. Archives Internationales de Physiologie de Biochimie et de Biophysique, Vol. 94 (1) (1986).

  • A.Cravador, P.Jacobs, A.Van Elsen, C.Lacroix, B.Colau, P.Van Alphen, A.Herzog, A.Bollen.Total DNA synthesis and cloning in Escherichia coli of a gene coding for the human growth hormone releasing factor; Biochimie, 67, 829 (1985).

  • M. Clarembeau, A. Cravador, W. Dumont, L. Hevesi, A. Krief, L. Lucchetti and D. Van Ende. Synthesis of selenoacetals; Tetrahedron, 41(21), 4793 (1985).

  • P. Jacobs, A. Cravador, R. Loriau, F. Brockly, B. Colau, P. Chuchana, A. Van Elsen, A. Herzog, A. Bollen. Molecular cloning sequencing and expression in Escherichia coli of human preprourokinase cDNA; DNA, 4(2), 139-146 (1985).

  • Moutschen, S., Wathelet, M., Cravador, A., Defilippi, P., Huez, G., Content, J. Molecular cloning of two genes induced by alpha-interferon in human cells; Progress in clinical and biological research, 202, 183-192 (1985).

  • A. Cravador. A síntese química de ADN - Um instrumento indispensável às manipulações genéticas; Química Nova, 8(2), 105 (1985).

  • A. Cravador. La synthèse chimique de ADN. Un outil indispensable aux manipulations génétiques; Chimie Nouvelle, 2 (6), 71 (1984).

  • A. Bollen, A. Herzog, A. Cravador, P. Hérion, P. Chuchana, A. Vander Straten, R. Loriau, P. Jacobs and A. van Elsen.Cloning and expression in Escherichia coli of full-length complementary DNA coding for human alpha1-antitrypsin; DNA, 2,(4), 255-264 (1983).

  • F. Michiels, G. Matthyssens, P. Kronenberger, E. Pays, B. Dero, S. Van Assel, M. Darville, A. Cravador, M. Steinert and R. Hamers. Gene activation and re-expression of a Trypanosoma brucei variant surface glycoprotein; The EMBO Journal, 2 (7), 1185-1192 (1983).

  • A. Cravador and A. Krief. Unusual reactivity of selenoboranes towards epoxides: new selective routes to hydroxyselenides and allylalcohols; Tetrahedron Letters, 22, 2491 (1981).

  • A. Krief, W. Dumont, A. Cravador, J. N. Denis, S. Halazy, L. Hevesi, D. Labar, J. Lucchetti, J. Rémion, M. Sevrin, D. Van Ende. Nouvelles méthodes de synthése utilisant une entité séléniée comme précurseur de fonction; Bull. Soc. Chim. France, II-519–II-529 (1980).

  • A. Cravador and A. Krief. Unexpectedly easy formation of alpha-seleno carbonyl compounds from vinyl selenides, J.C.S. Chem. Comm., 20, 951-952 (1980).

  • A. Cravador, A. Krief and L. Hevesi. Reduction vs acetalisation of some carbonyl compounds by means of methylselenol and Lewis Acids; J.C.S. Chem. Comm., 10, 451 (1980).

  • A. Cravador and A. Krief. Nouvelles méthodes de synthèse des méthylsélénoacétals et cétals; C.R.Acad.Sc.Paris, 289 (9), 267-269 (1979).

  • D. Van Ende, A. Cravador and A. Krief. 1,1-bis(phenylseleno) and 1,1-bis(methylseleno)alkyllithium as building blocks in organic synthesis, J.Organomet.Chem.,177 (1), 1-4 (1979).

  • A. Burton, L. Hevesi, W. Dumont, A. Cravador, A. Krief. Cleavage (Deprotection) of selenoketals to carbonyl compounds A comparative study, Synthesis, 11, 877-880 (1979). DOI: 10.1055/s-1979-28856.

  • A. Cravador, D. Linchamps, J. Pecher. Acidité relative des groupes méthyle de la 2,4,6-collidine dans le système phényllithium-solvants éthérés; Rev. Port, Quím., 20 , 65-69 (1978).

  • B. Tursch, D. Daloze, J. C. Braekman, C. Hootele, A. Cravador, D. Losman and R. Karlsson. Chemical ecology of Arthropods IX. Stucture and absolute configuration of hippodamine and convergine, two novel alkaloids from the american ladybug Hippodamia convergens; Tetrahedron Letters, 15(5), 409 (1974).

  • B. Tursch, D. Daloze, J. M. Pasteels, A. Cravador, J. C. Braekman, C. Hootele, D. Zimmermann. Two novel alkaloids from the american ladybug Hippodamia Convergens; Bull. Soc. Chim. Belges, 81, 649 (1972). DOI: 10.1002/bscb.19720810166.

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Contactos

Alfredo Jaime Morais Cravador
Universidade do Algarve
Faculdade de Ciências e Tecnologia
Laboratórios de Biotecnologia Molecular e Fitopatologia (G2,G3 e G4)
Campus de Gambelas
8005-139 FARO
PORTUGAL


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  Fax.: (+ 351) 289 800 066
   

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